This issue is pretty straightforward. Lex exposits to a curious Lena that his Amazo virus temporarily disables the abilities of metahumans and that he invented it as a way to contain the threat that he saw metahumans as posing to humans. But, he admits that the virus has changed in two ways that he didn't predict: it seems not to have been as temporary as he thought (laying low most of the Justice League) and it is causing humans to develop metahuman powers until "their cells burn out and they die." Whoops. Meanwhile, Batman, Superman, and Wonder Woman try to wrangle Patient Zero into the Lexcorp HQ so that Lex can try to work up a cure.
The only not straightforward part is, of course, the intriguing part. Lena listens to Lex's selfless story of wanting to save humans from metahumans and then reminds him that she knows when he's lying. She asks why he really created the cure, and he doesn't tell her. But, Lena isn't the only one hip to Lex's ways. Lex tells Captain Cold that he's worried that the virus is going to wipe out the Justice League, because it wasn't designed to do so, and Cold questions what he intended to do with it. Lex responds to him just as angrily as he did to Lena, leading us to want the answer to that questions all the more. I truly can't guess the answer, and I'm excited about that. We'll see where we go from here.
*** (three of five stars)